Publications

Hinshaw, S., Yuan, L., Noman, M. A., Martinez, M., Colombo, G., Dwyer, B., Ji, W., Romero, B., Forrest, I., Lu, J., Bian, J., Dunn, T., Garvin, E., Fernandez, D., Zhang, T., Gray, N., & Corsello, S. (2026). The molecular basis for nuclear pore destruction by a proximity-inducing molecular glue. Cell Chem Biol. https://doi.org/10.1016/j.chembiol.2026.04.016
Zhu, X., Byun, W. S., Pieńkowska, D., Nguyen, K., Gerhartz, J., Geng, Q., Qiu, T., Zhong, J., Wang, M., Sarott, R., Hinshaw, S., Zhang, T., Attardi, L., Nowak, R., & Gray, N. (2026). Activating p53Y220C with a Mutant-Specific Small Molecule. Nat Commun. https://doi.org/10.1038/s41467-026-72165-6
Zhuang, Z., Byun, W. S., Jakub, C., Kozicka, Z., Li, V., Abeja, D., Donovan, K., Sepic, S., You, I., Słabicki, M., Fischer, E., Hinshaw, S., Ebert, B., Schulman, B., & Gray, N. (2026). Charged molecular glue discovery enabled by targeted degron display. Nature Chem Biol. https://doi.org/10.1038/s41589-026-02182-5
Fu, S., Wang, L., Li, V., Lyu, X., Wei, W., Shi, X., Deng, S., Barber, J., Tahir, U., Adams, C., Carson, A., Hidalgo, B., Raffield, L., Wilson, J., Razumkov, H., Xiao, S., Spaas, J., Fernandez, D., Zhang, T., Gerszten, R., Benson, M., Gray, N., Hinshaw, S., & Long, J. (2026). A small molecule PTER-selective inhibitor reduces food intake and body weight. Cell Chem Biol. https://doi.org/10.1016/j.chembiol.2026.02.005
Qiu, T., Lee, Y. T., Dwyer, B., Tan, Y. J., Chen, T., Romero, B., Wang, Y., Deng, J., Zhang, T., Crabtree, G., Hinshaw, S., Wong, K.-K., & Gray, N. (2026). Design and Development of DNA Damage Chemical Inducers of Proximity for Targeted Cancer Therapy. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.5c17396
Li, Z., Martinez, M., Byun, W. S., Thathireddy, A., Qiu, T., Wang, Y., Katzengruber, L., Chouldjian, A., Lu, W., Ji, W., Che, J., Zhang, T., Hinshaw, S., & Gray, N. (2025). An AKR1C3-activated kinase inhibitor prodrug. RSC ChemBio. https://doi.org/10.1039/D5CB00219B
Yuan, L., Ji, W., Dwyer, B., Lu, J., Bian, J., Colombo, G., Martinez, M., Fernandez, D., Phillips, N., Tang, M., Zhou, C., Calla, N., Huancas, C., Eckart, M., Tran, J., Qiu, T., Doench, J., Rees, M., Roth, J., Cameron, M., Charville, G., Kuo, C., Dixon, S., Zhang, T., Hinshaw, S., Gray, N., & Corsello, S. (2025). Defining the antitumor mechanism of action of a clinical-stage compound as a selective degrader of the nuclear pore complex. Cancer Discovery. https://doi.org/10.1158/2159-8290.CD-25-0271
Jeon, E., Kim, Y., Ahn, H., Martinez, M., Hwang, K., Cho, S., Romero, B., Hinshaw, S., Gray, N., & Sim, T. (2025). Selective CDK6 Degradation via the KLHDC2 E3 Ubiquitin Ligase. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.5c02713
Hinshaw, S., Banik, S., & Gray, N. (2025). Generating Surprisingly Powerful Pharmacology from Chemically Induced Protein Interactions. Accounts of Chemical Research. https://doi.org/10.1021/acs.accounts.5c00225
Nix, M., Gourisankar, S., Sarott, R., Dwyer, B., Nettles, S., Martinez, M., Abuzaid, H., Yang, H., Wang, Y., Simanauskaite, J., Romero, B., Jones, H., Krokhotin, A., Lowensohn, T., Chen, L., Low, C., Davis, M., Fernandez, D., Zhang, T., Green, M., Hinshaw, S., Gray, N., & Crabtree, G. (2025). A Bivalent Molecular Glue Linking Lysine Acetyltransferases to Oncogene-induced Cell Death. biorxiv. https://doi.org/10.1101/2025.03.14.643404
Geng, Q., Jiang, Z., Byun, W. S., Donovan, K., Zhuang, Z., Jiang, F., Jones, H., Razumkov, H., Tang, M., Sarott, R., Fischer, E., Corsello, S., Hinshaw, S., & Gray, N. (2025). Development of Potent and Selective CK1α Molecular Glue Degraders. J Med Chem. https://doi.org/0.1021/acs.jmedchem.4c02415
Cai, J., Quan, Y., Zhang, C., Wang, Z., Hinshaw, S., Zhou, H., & Suhandynata, R. (2024). Concatemer-assisted stoichiometry analysis: targeted mass spectrometry for protein quantification. Life Sci Alliance. https://doi.org/10.26508/lsa.202403007
Razumkov, H., Jiang, Z., Baek, K., You, I., Geng, Q., Donovan, K., Tang, M., Metivier, R., Mageed, N., Seo, P., Li, Z., Byun, W. S., Hinshaw, S., Sarott, R., Fischer, E., & Gray, N. (2024). Discovery of CRBN-Dependent WEE1 Molecular Glue Degraders from a Multicomponent Combinatorial Library. J Am Chem Soc. https://doi.org/10.1021/jacs.4c06127
Ji, W., Du, G., Jiang, J., Lu, W., Mills, C., Yuan, L., Jiang, F., He, Z., Bradshaw, G., Chung, M., Jiang, Z., Byun, W. S., Hinshaw, S., Zhang, T., & Gray, N. (2024). Discovery of bivalent small molecule degraders of cyclin-dependent kinase 7 (CDK7). European Journal of Medicinal Chemistry. https://doi.org/10.1016/j.ejmech.2024.116613
Sarott, R., Gourisankar, S., Karim, B., Sabin, N., Yang, H., Dwyer, B., Simanauskaite, J., Tse, J., Abuzaid, H., Krokhotin, A., Zhang, T., Hinshaw, S., Green, M., Crabtree, G., & Gray, N. (2024). Relocalizing transcriptional kinases to activate apoptosis. Science. https://doi.org/10.1126/science.adl536
Schnitzler, G., Kang, H., Fang, S., Angom, R., Lee-Kim, V., Ma, X. R., Zhou, R., Zheng, T., Guo, K., Taylor, M., Vellarikkal, S., Sias-Garcia, O., Blomendal, A., Munson, G., Guckelberger, P., Nguyen, T., Bergman, D., Hinshaw, S., Cheng, N., Cleary, B., Aragam, K., Lander, E., Finucane, H., Mukhopadhyay, D., Gupta, R., & Engreitz, J. (2024). Convergence of coronary artery disease genes onto endothelial cell programs. Nature. https://doi.org/10.1038/s41586-024-07022-x
Deng, S., Cai, J., Harrison, S., Zhou, H., & Hinshaw, S. (2023). Recognition of centromere-specific histone Cse4 by the inner kinetochore Okp1-Ame1 complex. EMBO Reports. https://doi.org/10.15252/embr.202357702
Younghoon, K., Seo, P., Jeon, E., You, I., Hwang, K., Kim, N., Tse, J., Bae, J., Choi, H.-S., Hinshaw, S., Gray, N., & Sim, T. (2023). Targeted kinase degradation via the KLHDC2 ubiquitin E3 ligase. Cell Chemical Biology. https://doi.org/10.1016/j.chembiol.2023.07.008
Sarott, R., You, I., Li, Y.-D., Toenjes, S., Donovan, K., Seo, P., Ordonez, M., Byun, W. S., Hassan, M. M., Wachter, F., Chouchani, E., Slabicki, M., Fischer, E., Ebert, B., Hinshaw, S., & Gray, N. (2023). Chemical Specification of E3 Ubiquitin Ligase Engagement by Cysteine-Reactive Chemistry. Journal of the American Chemical Society. https://doi.org/10.1021/jacs.3c06622
Lu, W., Fan, M., Ji, W., Tse, J., You, I., Ficarro, S., Tavares, I., Che, J., Kim, A., Zhu, X., Boghossian, A., Rees, M., Ronan, M., Roth, J., Hinshaw, S., Nabet, B., Corsello, S., Kwiatkowski, N., Marto, J., Zhang, T., & Gray, N. (2023). Structure-Based Design of Y-Shaped Covalent TEAD Inhibitors. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.2c01548